Bioclinic Naturals Digest-ProGD HP, 60 VCaps

Provides fungal and bacterial proteases to hydrolyze proline-containing peptides that are difficult to digest, such as gluten and casein
Provides broad-spectrum carbohydrate digestion with plant-based papain, bromelain, and fungal digestive enzymes
High-potency formulation allows for easy dosing, with a 267 mg enzyme blend delivered in each vegetarian capsule
Completely suitable for vegetarians
Feature Summary
Digest-ProGD HP is a high-potency proprietary enzyme blend for comprehensive carbohydrate digestion. It provides fungal proteases derived from Aspergillus oryzae, bacterial protease from Bacillus subtilis, and comprehensive carbohydrate digestive support from papain, bromelain, and fungal digestive enzymes. Aspergillus oryzae extracts are rich in prolyl endopeptidases and dipeptidyl peptidase IV (DPP-IV) – a multifunctional serine protease that targets proline-containing peptides, such as those found in both gliadin and casein, both proteolytically resistant proteins.1−4

Indeed, protease activity from Aspergillus oryzae targets the proline-rich 33-mer of gliadin, perhaps the most immunotoxic peptide derived from gliadin. 5 The antigenic and immunomodulatory proline-rich proteins found in gluten are thought to trigger an inflammatory response in patients with either celiac disease or gluten sensitivity, often because of accidental gluten exposure, even for people on a gluten-free diet. 6 Supplementation with protease from Aspergillus oryzae has also been linked to a bifidogenic effect in animals, suggesting a potential probiotic effect, as well as an increase in gut-protective amino acids. 7,8

In addition to fungal and bacterial proteases, Digest-ProGD HP provides alpha-amylase, cellulose, and hemicellulose activity for comprehensive carbohydrate digestion support.

Medicinal Ingredients
Each Vegetarian Capsule Contains:
Enzyme Blend         267 mg
  Fungal Protease*1    690 FCC SAP    125.47 mg
  Bacterial Protease*2    75,000 FCC PC    75 mg
  Fungal Protease*1
    Providing 163 DPP-IV Enzyme Activity    6,700 FCC HUT    24.36 mg
  Alpha-Amylase*1    2,800 FCC DU    18.67 mg
  Bromelain*3    315,000 FCC PU    9.55 mg
  Papain*4    315,000 FCC PU    7.5 mg
  Cellulase*5    680 FCC CU    3.78 mg
  Hemicellulase*6    1,875 FCC HCU    2.34 mg
*1Aspergillus flavus var. oryzae (whole), *2Bacillus subtilis (whole), *3Ananas comosus var. comosus (pineapple stem), *4Carica papaya (fruit),*5Trichoderma longibrachiatum (whole), *6Aspergillus niger (whole)
FCC: Food Chemical Codex; SAP: Spectrophotometric Acid Protease Unit; PC: Protease Unit; HUT: Hemoglobin Unit on the Tyrosine Basis; DU: Dextrinizing Unit; PU: Papain Unit; CU: Cellulase Unit; HCU: Hemicellulase Unit.
Non-Medicinal Ingredients: Vegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant).

Recommended Adult Dose: 1 capsule 3 times per day with meals or as directed by a health care practitioner. Consult a health care practitioner for prolonged use.