Bioclinic Naturals EstroVantage EM, 90 VCaps

Offers a full array of protective compounds from cruciferous vegetables, including I3C, DIM, and sulforaphane
Provides a unique blend of botanicals that improve estrogen metabolism, shifting away from carcinogenic metabolites
Supports detoxification of a variety of environmental toxins as well as naturally produced hormones by enhancing phase 1 and phase 2 liver enzymes
Contains botanicals with potent anti-inflammatory activity 
Suitable for vegetarians/vegans 
Feature Summary
EstroVantage EM provides a comprehensive formula of plant-based compounds that improve the metabolism of estrogen and its metabolites. Cruciferous vegetables contain a variety of glucosinolates, which some studies have associated with a reduction in cancer incidence when consumed in greater amounts, most likely by causing a shift in metabolism to less carcinogenic estrogen metabolites.1,2 EstroVantage EM contains indole-3-carbinol (I3C) and its metabolite 3,3’-diindolylmethane (DIM), as well as sulforaphane from broccoli powder, all of which have been linked to lower rates of neoplastic changes and a more favourable estrogen profile.3-6 Not only do these glucosinolates improve estrogen metabolism, they also reduce inflammation by targeting key signalling molecules, such as Nrf2 and NF-κB.7,8 

EstroVantage EM also includes other potent plant compounds that reduce inflammation and block carcinogenic pathways. Silymarin, a milk thistle extract, down-regulates gene products involved in the proliferation of tumour cells, along with their invasion, angiogenesis, and metastasis. In addition, it enhances glucuronidation and maintains glutathione levels.9-11 This unique combination provides green tea polyphenols, lycopene (tomato extract), turmeric and rosemary extracts, as well as calcium D-glucarate, all of which have been shown to favourably shift estrogen metabolism and reduce carcinogenic risk.12-14 Most recently, a randomized, double-blind, placebo-controlled crossover study demonstrated that taking this formula led to markedly higher urinary levels of the protective 2-OHE1 estrogen metabolite and lower levels of the more dangerous 16α-OHE1 estrogen metabolite in premenopausal women.Most recently, a randomized, double-blind, placebo-controlled crossover study demonstrated that taking this formula led to markedly higher urinary levels of the protective 2-OHE1 estrogen metabolite and lower levels of the more dangerous 16α-OHE1 estrogen metabolite in premenopausal women.

Medicinal Ingredients: Suntheanine® L-Theanine 100 mg, 5-Hydroxy-L-Tryptophan (L-5-HTP) (Griffonia simplicifolia) (seed) 15 mg, Melatonin 1.5 mg.
Non-Medicinal Ingredients: Vegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant), silica.

3 capsules once per day with food or as directed by a health care practitioner. Consult a health care practitioner for use beyond 12 weeks.