Bioclinic Naturals Saffron Extract, 30 VCaps

Provides 28 mg of standardized saffron extract affron® per capsule
Affron is clinically validated in multiple trials
Contains standardized amounts of the bioactive components of saffron, crocin and safranal
Provides 100% pure Crocus sativus L. saffron from Spain
Helps support mood balance and reduce the symptoms of perceived stress, such as fatigue, weariness, and irritability
Helps improve restorative sleep and sleep quality in individuals experiencing sleeplessness
Helps support mood balance in adolescents and youth 12 years and over
Non-GMO, non-irradiated, and suitable for vegetarians/vegans
Feature Summary
Saffron is a spice derived from the Crocus sativus flower. It is rich in bioactive compounds and has been clinically shown to improve symptoms related to stress, anxiety, and low mood, along with enhancing sleep. Saffron’s active constituents include carotenoids, phenols, and flavonoids. Its clinical effects are primarily attributed to crocin and safranal, which are also responsible for its aroma and colour.1–3 Multiple controlled trials have shown that saffron improves symptoms related to nervousness, stress, and mood.4,5

Multiple mechanisms of action have been identified for saffron, including antioxidant and anti-inflammatory effects, modulation of the HPA axis, agonism of the GABAA receptor, and inhibition of the reuptake of several neurotransmitters, including dopamine.3,6,7 Affron, a novel standardized extract of saffron, has been shown to decrease negative mood and symptoms related to stress and anxiety (including perceived stress and nervousness, tension, sadness, and fatigue) in several randomized, controlled trials of adults, with similar benefits in a controlled trial of adolescents aged 12–16.8–10 Affron also improved clinician-assessed scores of mood when combined adjunctively with standard therapies.11 Additionally, affron has been shown to improve the sleep quality of participants with self-reported sleep problems and to increase evening melatonin levels.

Medicinal Ingredients: Saffron Extract (affron®) (Crocus sativus) (stigma) 28 mg,   (3.5% Lepticrosalides® containing crocins and safranal)
Non-Medicinal Ingredients: Vegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant), stearic acid, silica.

Adults (Mood, Symptoms of Stress, Nervousness, Sleep Quality): 1 capsule per day or as directed by a health care practitioner. Consult a health care practitioner for use beyond 12 weeks. For sleep quality, consult a health care practitioner for use beyond 4 weeks.
Adolescents Over 12 Years of Age (Mood): 1 capsule per day or as directed by a health care practitioner. Consult a health care practitioner for use beyond 8 weeks